Endocrine Abstracts

Excess body iron is associated with the metabolic syndrome, but whether it has a causal role in the pathophysiology of insulin resistance (IR) is not well understood. Aim of this study was to assess (a) the effect of dietary modulation of iron status on IR in Wild-type or ob/ob C57Bl/6 male mice fed a standard iron concentration (8 mg/kg) or an iron enriched diet (30 g/kg; IED), as well as in high-fructose diet (HFD) mice and (b) to investigate the mechanisms whereby. IED dete...